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Archived news – Decoding SARS-CoV-2

Largest Study to Date of COVID-19 Susceptibility Launched (March 31) – The new study, launched by the Hannover Medical School in Germany, is intended to identify genomic and other biological factors of patient susceptibility and is supported by a range of genomics and technology companies including Rescale, Amazon Web Services (AWS), Bionano Genomics, Genoox, and other companies associated with Tech Against Covid. The study involves 1,000 patients and controls – consisting of COVID-19 patients and their partners and first-degree relatives as controls – and will compare a variety of genomic and other biological variables between those patients who show no or mild symptoms and those who show severe illness. Partners have typically been intensely exposed to the same strain of the virus as the patients, and differences in disease severity can be caused by genetic variation.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing (March 23) – 26 of the 29 viral proteins were cloned, tagged and expressed in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), which identified 332 high confidence SARS-CoV-2-human protein-protein interactions (PPIs).

Adaptive Biotechnologies and Microsoft expand partnership to decode COVID-19 immune response and provide open data access (March 20)

SARS-CoV-2_Sequencing (March 19) – The CDC has started a collection of SARS-CoV-2 sequencing and bioinformatic protocols, metadata guidance, scripts/workflows, links and best practices.

The proximal origin of SARS-CoV-2 (March 17) – Demonstrates that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.

Over 24,000 coronavirus research papers are now available in one place (March 16) – A database with over 24,000 research papers related to the coronavirus pandemic is now live. The database not only helps scientists consolidate existing research but also makes the body of literature easier to mine for insights with artificial intelligence.

The Establishment of Reference Sequence for SARS-CoV-2 and Variation Analysis (March 13) – The SARS-CoV-2 reference sequence could benefit not only biological study of this virus but also diagnosis, clinical monitoring and intervention of SARS-CoV-2 infection in the future.

Why does the coronavirus spread so easily between people? (March 6) – To infect a cell, the coronaviruses use a ‘spike’ protein that binds to the cell membrane. Its spike protein differs from those of close relatives, and suggest that the protein has a site on it which is activated by a host-cell enzyme called furin. Furin is found in liver, lung, and small intestines which explains the symptoms associated with coronavirus infection – still little is know whether this is exactly what is happening and the importance of these activation sites.

Two genome sequences of coronavirus (COVID-19) show possible internal transmission (March 4) – Scientists have published two genome sequences for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2.

Coronavirus Method Development Community – This group is for the support of researchers working on coronavirus methods, intended to facilitate method-centered collaboration and sharing.

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